Feature in our Nature journal supplement on cell and gene therapy

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Cell and gene therapy Spotlight:

Publication monthType of issueBiopharma Dealmakers
issues themes / tech
Conference distributionSpotlight region
Booking deadline
February
Online collectionMetabolic diseases - including obesity and diabetesBIO-Europe Spring (Milan, 17 - 19 March)

American Association for Cancer Research (AACR) annual meeting (Chicago, USA, 25 - 30 April)

Bio-Trinity (London, UK, 1 - 2 April)
12 Nov 2024
MarchFull issueOncology - solid tumours

Drug delivery
BIO-Europe Spring (Milan, 17-19 March)

American Association for Cancer Research (AACR) annual meeting (Chicago, USA, 25 - 30 April)

Bio-Trinity (London, UK, 1 - 2 April)
Canada3 Dec 2024
MayOnline collectionPrecision medicine - including genetic sequencing, gene editing and molecular diagnosticsBio International Convention (Boston, 16 - 19 June)12 Feb 2025
JuneFull issueInfectious diseases - including AMR

AI/ML/Big data, generative AI
Bio International Convention (Boston, 16 - 19 June)East coast USA including Boston, New York and Philadelphia3 Mar 2025
JulyOnline collectionRNA technologies
Nucleic-acid based drugs
BioPharm America (Boston, USA, 11 - 12 September)

Bio-Europe (Vien
na, 3 - 5 November)

Society for Neuroscience annual meeting (San Diego, USA, 15 -19 October)
9 Apr 2025
September Full issueNeurodegenerative disorders - including Alzheimer’s disease and dementia and/or Aging/longevity

Antibody technologies, including ADCs
BioPharm America (Boston, USA, 11 -12 September)

Bio-Europe (Vienna, 3 - 5 November)

Society for Neuroscience annual meeting (San Diego, USA, 15 -19 October)
Europe3 Jun 2025
OctoberOnline collectionProtein technologies - including protein degradationJP Morgan/Biotech Showcase (San Francisco, USA, 2026)
15 Jul 2025
NovemberOnline collectionHaematological disorders - including blood clotting and haemophiliaJP Morgan/Biotech Showcase (San Francisco, USA, 2026)
15 Aug 2025
DecemberFull issueOncology - approaches used in treatments, including nanomedicines and radiopharmaceuticals

Regenerative medicine (including CRISPR, cell & gene therapies, gene editing)
JP Morgan/Biotech Showcase (San Francisco, USA, 2026)
USA (San Francisco & Texas)1 Sep 2025

With the rapid improvement of ‘chimeric antigen receptor’ (CAR) T-cell treatments for cancer, cellular therapies are having a moment.

CAR-T cells are a form of immunotherapy, in which a patient’s own immune cells are genetically programmed to attack cancerous cells. Other therapeutic strategies could replace damaged or missing cells, such as the islet cells that produce insulin.

Whatever their target, cell therapies are promising, but expensive and technically challenging. And each batch of cells must be customized to the patient: because the immune system attacks foreign cells, one individual’s cells cannot be used to treat another’s disease.

So, some researchers are pursuing a ‘universal’ stem cell approach. Stem cells – progenitor cells that can be chemically coaxed into any desired cell type – are genetically modified to help them fly under the immune system’s radar, for instance by removing or modifying certain proteins using gene editing. Such cells could theoretically be applied to all (or at least many) patients, reducing cost and speeding treatment.

But stem cells present challenges of their own: a cell that can evade the immune system is one that could theoretically run amok in the body.

 


 

About Nature Spotlights:

Nature Spotlight

Nature Spotlights are special features published in the Nature journal, profiling a specific area of scientific interest.

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