Feature in our Nature journal supplement on cell and gene therapy
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Cell and gene therapy Spotlight:
Publication month | Type of issue | Biopharma Dealmakers issues themes / tech | Conference distribution | Spotlight region | Booking deadline |
---|---|---|---|---|---|
February | Online collection | Metabolic diseases - including obesity and diabetes | BIO-Europe Spring (Milan, 17 - 19 March) American Association for Cancer Research (AACR) annual meeting (Chicago, USA, 25 - 30 April) Bio-Trinity (London, UK, 1 - 2 April) | 12 Nov 2024 | |
March | Full issue | Oncology - solid tumours Drug delivery | BIO-Europe Spring (Milan, 17-19 March) American Association for Cancer Research (AACR) annual meeting (Chicago, USA, 25 - 30 April) Bio-Trinity (London, UK, 1 - 2 April) | Canada | 3 Dec 2024 |
May | Online collection | Precision medicine - including genetic sequencing, gene editing and molecular diagnostics | Bio International Convention (Boston, 16 - 19 June) | 12 Feb 2025 | |
June | Full issue | Infectious diseases - including AMR AI/ML/Big data, generative AI | Bio International Convention (Boston, 16 - 19 June) | East coast USA including Boston, New York and Philadelphia | 3 Mar 2025 |
July | Online collection | RNA technologies Nucleic-acid based drugs | BioPharm America (Boston, USA, 11 - 12 September) Bio-Europe (Vien na, 3 - 5 November) Society for Neuroscience annual meeting (San Diego, USA, 15 -19 October) | 9 Apr 2025 | |
September | Full issue | Neurodegenerative disorders - including Alzheimer’s disease and dementia and/or Aging/longevity Antibody technologies, including ADCs | BioPharm America (Boston, USA, 11 -12 September) Bio-Europe (Vienna, 3 - 5 November) Society for Neuroscience annual meeting (San Diego, USA, 15 -19 October) | Europe | 3 Jun 2025 |
October | Online collection | Protein technologies - including protein degradation | JP Morgan/Biotech Showcase (San Francisco, USA, 2026) | 15 Jul 2025 | |
November | Online collection | Haematological disorders - including blood clotting and haemophilia | JP Morgan/Biotech Showcase (San Francisco, USA, 2026) | 15 Aug 2025 | |
December | Full issue | Oncology - approaches used in treatments, including nanomedicines and radiopharmaceuticals Regenerative medicine (including CRISPR, cell & gene therapies, gene editing) | JP Morgan/Biotech Showcase (San Francisco, USA, 2026) | USA (San Francisco & Texas) | 1 Sep 2025 |
With the rapid improvement of ‘chimeric antigen receptor’ (CAR) T-cell treatments for cancer, cellular therapies are having a moment.
CAR-T cells are a form of immunotherapy, in which a patient’s own immune cells are genetically programmed to attack cancerous cells. Other therapeutic strategies could replace damaged or missing cells, such as the islet cells that produce insulin.
Whatever their target, cell therapies are promising, but expensive and technically challenging. And each batch of cells must be customized to the patient: because the immune system attacks foreign cells, one individual’s cells cannot be used to treat another’s disease.
So, some researchers are pursuing a ‘universal’ stem cell approach. Stem cells – progenitor cells that can be chemically coaxed into any desired cell type – are genetically modified to help them fly under the immune system’s radar, for instance by removing or modifying certain proteins using gene editing. Such cells could theoretically be applied to all (or at least many) patients, reducing cost and speeding treatment.
But stem cells present challenges of their own: a cell that can evade the immune system is one that could theoretically run amok in the body.
About Nature Spotlights:
Nature Spotlights are special features published in the Nature journal, profiling a specific area of scientific interest.