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Organoids: moving in vivo
Organoids are three-dimensional structures that are derived from human cells. Because they are multidimensional, they can better capture features of their original tissues, be it an organ or a tumor, and thus can be a step up from simple cell lines grown in flat dishes. Organoids can be complex, but they are still not as complex as a living body. To take organoids even further, many researchers are upping the complexity of the cues they receive by trying to transplant them in vivo.
Integrating an organoid into a living host comes with a suite of challenges—where and when to do the transplant? How to avoid a mouse rejecting cells derived from a human? But successful integration into a rodent host affords researchers the opportunity to ask more relevant questions about health and disease in a more appropriate biological context.
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