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Emerging models: wild fishes with clinical phenotypes
Conventional laboratory species are invaluable for modeling human disease. But models they often are; in many cases, they are manipulated to mimic diseases they would not get normally. What if there were more natural options available to study a disease? Some researchers are looking to the wild for alternatives.
This Technology Feature will consider three fishes with naturally occurring phenotypes that, when found in humans, are associated with pathology. These include: Antarctic icefish, with porous bones and no red blood cells; Mexican cavefish, with unique means of energy metabolism and storage; and the killifish of the Northeast, exposed to numerous pollutants to seemingly little ill effect.
This Technology Feature Will Cover: