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Introducing the Technology Features
These editorially-independent features, published in the Nature and Nature Methods print journals and online on nature.com, spotlight scientists, the technology, and the methods they choose – their views of what works and what does not – providing key information that scientists globally can implement in their own labs.
25 Technology Features are being published in Nature and Nature Methods throughout 2020, and in September, Nature Methods is publishing its next Technology Feature on Proteins.
‘How cryo-EM reveals molecular motions’
Cryo-electron microscopy (cryo-EM) is a powerful technique used to solve the 3D structures of proteins and other biomolecules. Improvements over the past decade to electron microscope instruments, to sample preparation methods, and to computational analysis methods, now allow protein structures to be routinely solved at atomic resolution.
The next frontier of cryo-EM is to resolve multiple heterogeneous structures of the same biomolecule. Some researchers are developing time-resolved sample preparation methods to freeze biomolecules in different states as they carry out their molecular functions. Other researchers are applying computational tricks to sort different molecular states or make movies of continuous molecular motions.
The Technology Feature will cover:
- Computational sorting of molecular states
- Ways to freeze molecular states
- Relating molecular movements to functions
Publication & Publication Date: Nature Methods, September 2020
Ad Booking Deadline: August 18, 2020
Ad Materials Due: August 19, 2020
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