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Nature Methods Technology Feature – Tools and reagents

Booking Deadline Mar 15
Publication Name:
Nature Methods
Materials Due:
Mar 18
Tools and reagents
Publication Date:
Apr 01

Don’t miss this opportunity to target an engaged audience interested in Cancer!

Tools and reagents: Chromatin-immunoprecipitation

By using chromatin-immunoprecipitation (IP) which is crosslinking, ‘pull-down’ with antibodies followed by sequencing (ChIP-seq), labs can explore gene function. They might use other related methods such as DNA immunoprecipitation plus sequencing (DIP-seq) to leverage the ‘pull-down’ of immunoprecipitation to profile DNA modifications.

When using such techniques, much experimental troubleshooting is needed to obtain robust, reproducible results. Many artifacts need to be excluded that can make data difficult, and sometimes, impossible to interpret.

This Technology Feature will cover:

  • Avoiding artifacts with ChiP-seq, DIP-seq and related methods
  • Experimental design for IP-experiments
  • Validation approaches for using immunoprecipitation

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